Coupling reaction between electron-rich pyrimidinones and α-amino acids promoted by phosphonium salts.
نویسندگان
چکیده
Coupling reaction between electron-rich 2-morpholino-4(3H)-pyrimidinone and nucleophilic side chains of several natural α-amino acids promoted by phosphonium salt has been developed to prepare new optically active pyrimidin-4-yl amino acids. The best results were obtained using a two-step method through the easily available benzotriazolyl-1-oxy intermediate. A detailed optimization study of this reaction is discussed.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 9 17 شماره
صفحات -
تاریخ انتشار 2011